Redefining radiologic response for patients with malignant pleural mesothelioma

Аннотация

The current standard for medical image-based tumor response assessment for patients with malignant pleural mesothelioma is the modified Response Evaluation Criteria In Solid Tumors (RECIST) measurement technique with changes classified according to the standard RECIST response classification criteria. While the modified RECIST measurement technique was developed specifically for the unique morphology and growth patterns of mesothelioma, the standard RECIST classification criteria are used across a wide range of diseases and are certainly not specific to any one disease. As a coherent progression, this work extends the definition of radiologic response for patients with malignant pleural mesothelioma from one to three dimensions, both in the context of a discrete classification system and as a continuous prognostic model. Furthermore, temporal and spatial measurements are combined in an investigation of dynamic imaging for patients with mesothelioma.