State of APUD- system of lung in conditions of organ development and pathology

Аннотация

The aim of the study was to determine the features of the structural organization of the APUD-system of human lungs at different stages of embryonic development, as well as during inflammatory and tumor processes in them. The lungs of human fetuses and newborns, as well as children who died from respiratory diseases and in cancer patients were studied by histological methods. Fragments of the lungs are fixed in Bouin's fluid and embedded in paraffin. General histological methods were used: hematoxylin and eosin, according to the method of Van Gieson and Weigert. Argyrophilic neuroendocrine structures are impregnated with silver nitrate according to the Grimelius method. Already at the tubular and alveolar stages of lung histogenesis, single neuroendocrine cells (apudocytes), later neuroepithelial bodies, are determined.