LOCAL ANTI-INFLAMMATORY EFFECT OF GEL CONTAINING CONVOLVULUS ARVENSIS EXTRACT

Аннотация

Many plants have been known to cure various diseases since ancient times. Even the oldest examples of writing, created in the years before Christ, contain information about the healing properties of plants. Some natural drugs considered valuable were isolated in pure form decades ago. But there are many plants that have not yet been studied and whose medicinal properties have not been scientifically tested. Аннотация: Кўпгина ўсимликларнинг турли касалликларга даво бўлиши инсонларга жуда қадим замонлардан бери маълум. Милоддан олдинги йилларда яратилган энг қадимги ёзув намуналарида ҳам, ўсимликларнинг шифобахш хоссалари тўғрисида маълумотлар бор. Қимматли бўлиб ҳисобланган баъзи табиий дорилар бундан бир неча ўн йил илгари соф ҳолда ажратиб олинди. Аммо ҳали ўрганилмаган, шифобахш хусусиятлари илмий асосда текшириб кўрилмаган ўсимликлар кўп. Key words: Phlogogens, medicinal substance, alkaloids, histamine, dextran, leaf sap. Калит сўзлар: Флогогенлар, доривор модда, алкалоидлар, гистамин, декстран, барг шираси. A number of scientific studies are being conducted around the world to improve the effectiveness of anti-inflammatory drugs and prevent side effects. Despite the wide range of anti-inflammatory drugs currently used in practice, there remains a high demand for new drugs that exhibit high pharmacological activity, low toxicity, and minimal side effects. https://scientific-jl.org/obr Выпуск журнала №-71 251 Часть–3_ июня–2025 ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ 2181- 3187 The purpose of the study. A study of the effect of a hydrogel containing a field ivy extract on the exudative stage of inflammation. One such plant is the field ivy, a member of the ivy family, which is widespread in all regions of Uzbekistan. The peoples of Central Asia call this plant by various names. The Turkmen call it cherapechak, the Kazakhs call it shermatik, the Turks call it chermashyk, and the Russians call it vyunok polevoy. The Institute of Plant Chemistry of the Academy of Sciences of Uzbekistan has made a great contribution to the discovery of medicinal plants and the extraction of alkaloids from them. The effect of medicinal plants on the body depends on the amount of chemical compounds in their composition. These compounds are concentrated in different amounts in different parts of the plant. Medicinal substances are concentrated in the shoots, leaves or fruits of some plants, and in others in the roots or bark. Therefore, the part of the plant that contains the most biologically active substances is mainly collected [9,10- 37, 372]. The field ivy plant is a perennial herbaceous plant from the Ivy family, growing as a creeper or creeper, with a stem length of 40-100 cm. Its leaves are arcuate, lanceolate with a sharp tip. The field ivy blooms in March-April. It blooms in March- August. The flowers are white or pink, trumpet-shaped. The fruits ripen in June- September. The appearance of the fruit is wide ovoid, hairless length is 6-8 mm. Field ivy grows abundantly on irrigated land. It is spread everywhere in our republic. In order to prepare medicines from the plant, the above-ground part of the plant is collected and dried in a cool and shady place. The above-ground parts of the plant contain flavonoids, caffeic acid, carotene, vitamin C, resins and some alkaloids. Many medicinal preparations are prepared from this plant. The raw juice of the plant's leaves, mixed with beef fat, was used as a remedy for lung and ear diseases. A decoction prepared from the above-ground part of the plant was used to wash wounds and bruises. In addition, a decoction was used as a medicine against scabies and lice. A powder made from the leaves was sprinkled on wounds and various injuries [4,5-32, 284]. The scientific significance of the results of the research is that it is used for the first time in the form of a gel from local plant sources, the possibility of finding among https://scientific-jl.org/obr Выпуск журнала №-71 252 Часть–3_ июня–2025 ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ 2181- 3187 them highly effective agents that stimulate anti-inflammatory properties, and the main aspects of the mechanism of action of the gel containing the extract of field ivy are highlighted [13, 88]. Materials and research methods. As the object of the study, a gel prepared from a complex of biologically active substances extracted from the above-ground parts of the field ivy plant was taken. The anti-inflammatory effects of ivy extract preservative gel were compared to ibuprofen gel. Because the inflammatory process is complex, choosing drugs that work against it is difficult [6, 340]. The anti-inflammatory effect of the studied drugs is determined by the difference between the growth in the volume of the paws of the experimental and comparison groups of animals or the difference between the amputated paws of mice. White rats with a mass of 155-180 g were used to perform the tasks set before us. Formalin, dextran, histamine, seroto