FREQUENCY OF MYCOSES IN PATIENTS WITH DRUG-RESISTANT PULMONARY TUBERCULOSIS

Аннотация

One of the current problems of phthisiology is the high incidence of tuberculosis among HIV-infected patients. The prevalence of these diseases in the same population groups causes their frequent association with each other, which makes the prognosis of combined pathology extremely unfavorable. The emergence of multiple drug resistance in Mycobacterium tuberculosis has become a serious threat to the effectiveness of anti-tuberculosis programs in many countries of the world [ 1] . The growth of the HIV epidemic is also reflected in the situation with drug-resistant tuberculosis, which is also associated with impaired anti-tuberculosis immunity [4]. The high frequency of multiple drug resistance in Mycobacterium tuberculosis (resistance to the most effective anti-tuberculosis drugs isoniazid and rifampicin ) clearly and directly correlates with the prevalence of HIV infection [3]. Drug resistance in Mycobacterium tuberculosis is one of the main factors limiting the effectiveness of anti-tuberculosis therapy. The prevalence of resistant forms of Mycobacterium tuberculosis in newly diagnosed patients with tuberculosis and HIV infection is higher than in patients with tuberculosis without HIV infection (2% versus 0.4%).