Diagnostic Value of VEGF And Ki-67 Expression in Predicting Recurrence Risk in Ovarian Cancer

Аннотация

This article assesses the clinical and prognostic value of VEGF and Ki-67 immunohistochemical markers in patients diagnosed with ovarian cancer. A total of 130 patients treated at the Tashkent Regional Branch of the Republican Oncology and Radiology Center between 2018 and 2022 were included in the study. Expression of the markers was evaluated using H-score and percentage index methods. Results demonstrated that high levels of VEGF and Ki-67 expression were significantly associated with increased recurrence risk (p 20% are classified as aggressive. Loizzi et al. tumor's growth rate. In ovarian cancer, high Ki-67 (2013) found that patients with Ki-67 >40% had 2.5 expression indicates aggressive tumor behavior, times higher recurrence rates. increased biological activity, and reduced sensitivity to treatment. Consequently, such patients often A meta-analysis by Morice et al. (2012) found that experience rapid and severe recurrence. patients with high Ki-67 expression had a 1.7 times higher recurrence risk and significantly lower overall Scientific and Practical Relevance: Studies survival. Mahdi et al. (2014) reported that even in early- demonstrate that combined evaluation of VEGF and Ki- stage OC, high Ki-67 expression predicted recurrence. 67 provides a more comprehensive