Seldin and giebisch's The Kidney Physiology and Pathophysiology

Аннотация

The first edition of The Kidney: Physiology and Pathophysiology was published in 1985. Even at that early period, an abundance of books on kidney disease were in circulation. In general, the principal emphasis was on discrete renal disease, often presented as an isolated phenomenon, independent of the physiologic background generating the disease process. In part, this focus on the descriptive aspects of a disease was the consequence of the lack of basic understanding of the underlying pathophysiologic processes. In large measure, however, the analysis of abnormal kidney function in terms of discreet disease entities was also a conceptual model, derived largely from the triumphs in infectious disease, where a causal root to a disease could be unambiguously identified. The concept of abnormal function as an expression of deranged physiologic regulation was only dimly perceived.