Ревматолог тәжірибесіндегі шегрен ауруы (әдебиетке шолу)

Аннотация

Most researchers consider Szogren's disease as a consequence of immunopathological reactions to viral antigens. Potential etiologic candidates are sialotropic or omphotropic viruses. Isolation of viral particles from the affected tissue of salivary glands, the presence of antiviral antibodies, as well as molecular mimicry between viruses and autoantigens, suggests the possible participation of viruses. Nevertheless, there is no direct evidence of a viral etiology of the disease. The role of genetic factors in pathogenesis is considered in connection with a clear tendency to detect an increased number of cases in families and the presence of autoantibodies and other autoimmune diseases in relatives.