Dynamics of changes in the level of cytokines in blood serum and in nasal secretions in patients with chronic rhinosinusitis

Аннотация

The article presents data on the dynamics of changes in the level of cytokines in the blood serum and in nasal secretions in patients with chronic rhinosinusitis. There were studies of 48 patients who were under our supervision at the age of 14 to 56 years. Thus, the study showed that chronic forms of rhinosinusitis develops against the background of multidirectional shifts in the concentration of anti-inflammatory cytokines in blood serum and nasal secretions. An in-crease in the concentration of IL-8 in the nasal secretion, which is a powerful chemokine, in combination with an increase in the level of IL-1, IL-2 and IL-6 (primary anti-inflammatory cytokines) leads to a complication of the process and pro-longed persistence of the microbial flora.