DIAGNOSIS AND TREATMENT OF CHRONIC BRUCELLOSIS

Аннотация

Под наблюдением 85 пациентов в возрасте от 17 до 74 лет. У всех пациентов использовались стандартные общие, серологические, биохимические и статистические методы. Больные по клиническим формам распределились следующим образом: первичный хронический бруцеллез (ПХБ) - 22 (25,8%) и вторичный хронический бруцеллез (ВХБ) - 63 (74,2%). Фаза субкомпенсации наблюдалась у 62,3% обследованных пациентов, фаза декомпенсации выявлена у 37,7%. Ключевые слова: хронический бруцеллез, клиника, диагностика, антиоксидантная система, этиопатогенетическое лечение Выпуск журнала №-27 Часть–4_Июнь –2025 411 MODERN EDUCATION AND DEVELOPMENT Сурункали бруцеллёз диагностикаси ва даволаш Фарманова Махтоб Алимовна - farmanova.maxtob@bsmi.uz Абу Али Ибн Сино номидаги Бухоро Давлат тиббиёт институти (Бухоро, Ўзбекистон) Аннотация: Назоратимиз остидаги 85 нафар 17-74 ёшгача бўлган беморни кузатдик. Барча беморларда standart умумий, серологик, биокимёвий ва статистик усуллар қўлланилган. Клиник шаклларга кўра беморлар қуйидагича тақсимланди: бирламчи сурункали бруцеллёз (БCБ) - 22 (25,8%) ва иккиламчи сурункали бруцеллёз (ИСБ) - 63 (74,2%). Субкомпенсация босқичи кўриб беморларнинг 62,3% кузатилди, декомпенсация босқичи 37,7% нозил қилинган. Калит сўзлар: сурункали бруцеллёз, клиникаси, диагностикаси, антиоксидант тизими, етиопатогенетик даволаш According to WHO, the annual incidence of brucellosis is 500 million people. According to M. Avijgan et al., the number of patients with brucellosis is actually 10- 25 times higher than those who were registered with this disease [1]. According to Academician G.G. Onishchenko, among 100,000 people, the greatest spread of brucellosis was observed in Nepal, the United Arab Emirates, Jordan, Egypt, and Turkey [2]. The etymological state of brucellosis in Russia is unstable and the incidence per 100 thousand of the population is 0.2-0.7 [3]. Among the countries of the Commonwealth, i.e. in Kyrgyzstan [5], Georgia, Azerbaijan [2], Kazakhstan [4], Uzbekistan [2], Tajikistan [6] and Turkmenistan, the incidence of brucellosis remains high, they are among the 25 countries with the highest indicators of the spread of brucellosis [3]. In Uzbekistan, the incidence of brucellosis per 100 thousand population is from 1.8 to 2.8 [7; 9]. In chronic active brucellosis (CAB), patients from time to time complain of fever, trembling, sweating, weakness, shortness of breath, pain in the muscles, joints, spine, headaches, numbness in the morning, cold on the upper and lower extremities, Выпуск журнала №-27 Часть–4_Июнь –2025 412 MODERN EDUCATION AND DEVELOPMENT dyspeptic symptoms, weakening cognitive functions [8,10]. According to scientists, clinical, laboratory and functional examinations are associated with changes and multifocal fibrosis of organs and tissues of the body, as well as an increase in lymph nodes, the direct spread of Brucella to all organs and tissues of the body, which will lead to multiple organ insufficiency [11]. Various infectious factors in the body activate free radical processes. Multiple organ failure that develops in chronic active brucellosis is largely associated with increased hemodynamic disorders, lipid peroxidation (LPO). And this requires the improvement of medical procedures. To date, large-scale measures are being implemented in our country aimed at providing the population with cheap and high- quality medicinal and import-substituting drugs produced from local raw materials. In this direction, it is very important to meet the demand of the population for cheap pharmaceutical products through the creation of new drugs based on local raw materials that are not inferior in efficiency to their foreign counterparts. Purpose: Evaluation of the effectiveness of the treatment of patients with chronic active brucellosis with phosphargin succinate. Research materials and methods used 85 patients aged 17-74 who were treated in the Bukhara Regional Hospital for Acute Diseases, living in regional endemic areas, were taken as the object of the study. 64 (75.3%) of them are men and 21 (24.7%) are women. Distribution of patients by age according to the WHO classification showed that the incidence is mainly characteristic of young age (78.5%). The average age of the patients was 36.18±1.99 years. According to the International Classification of Diseases (ICD-10), brucellosis is included in the "bacterial zoonoses" block and is assigned A23 code A23.0. Brusella melitensis and A23.1. Brucellosis transmitted by Brusella abortus is considered [Tenth revision - Geneva, 2003]. When making a diagnosis of chronic brucellosis used RCHD - Republican Center for Health Development of the Russian Federation. According to this classification, it was divided into primary chronic brucellosis (PCHB) and secondary chronic brucellosis. Each patient who came to the Выпуск журнала №-27 Часть–4_Июнь –2025 413 MODERN EDUCATION AND DEVELOPMENT hospital underwent a clinical examination, an objective examination, and was dia