INNOVATIVE INTERVENTIONAL APPROACHES TO CORONARY ARTERY THROMBOSIS IN ACUTE CORONARY SYNDROME

Аннотация

This study analyzes the clinical and angiographic outcomes of various interventional strategies used in the treatment of total coronary artery thrombosis in patients with acute coronary syndrome (ACS). A total of 120 patients were included and divided into groups based on the method of intervention: standard PCI, thrombus aspiration, GP IIb/IIIa inhibitors, and intravascular imaging (IVUS/OCT). Key outcomes included TIMI flow, myocardial blush grade, and 30-day MACE (major adverse cardiac events). Results revealed that combined approaches showed superior reperfusion outcomes and reduced complications. The findings suggest that personalized, multimodal interventional strategies are more effective in managing total thrombotic occlusions. Keywords: Acute coronary syndrome, total thrombus, PCI, thrombus aspiration, GP IIb/IIIa inhibitors, IVUS, OCT, TIMI flow, MACE. Relevance Total coronary artery thrombosis is among the most critical forms of acute coronary syndrome (ACS), often leading to extensive myocardial damage and high mortality. Immediate and effective reperfusion is essential to prevent irreversible ischemic injury. While percutaneous coronary intervention (PCI) remains the cornerstone of treatment, the choice of technique in the setting of heavy thrombotic burden remains controversial. Recent advances such as thrombus aspiration, potent antiplatelet therapy (e.g., GP IIb/IIIa inhibitors), and intravascular imaging technologies (IVUS, OCT) offer promising solutions. However, standardized protocols for their optimal use in total occlusions are lacking. Comparative analysis of these strategies is vital to identify the most effective approach, reduce adverse events, and improve patient outcomes. This study provides critical insights into the clinical utility of different interventional methods and supports the need for algorithm-based, individualized treatment in patients with ACS and complete coronary artery occlusion. 59 ACADEMIC RESEARCH IN MODERN SCIENCE International scientific-online conference Aim of the Study: To compare the clinical effectiveness of various interventional techniques in the treatment of total coronary artery thrombosis in patients with acute coronary syndrome.