CARDIOVASCULAR CONSEQUENCES OF INSULIN RESISTANCE: AN OVERVIEW OF CURRENT EVIDENCE

Аннотация

However, the literature on the role of NTG as RF CHD differs significantly. Meanwhile, in somecases, NTG can precede thedevelopment ofDM and,in acertain sense, it can be considered as a state of "pre-disease" in relation to DM. Hyperglycemia, including latent hyperglycemia, often proceeds with hyperinsulinemia, which is considered one of the components of the "metabolic" syndrome. which plays an important role in the formation of cardiovascular diseases, including coronary artery disease. Key words:Blood pressure, hyperlipidemia, obesity, diabetes mellitus. Topicality. The epidemiological situation with regard to coronary heart disease (CHD) in different regions of the world and in individual populations is very ambiguous. More than 1 million Americans had new cases of CHD or exacerbations of this disease (qualified as myocardial infarction or fatal CHD). Moreover, 650,000 of them had newly diagnosed CHD, and 350,000 had an exacerbation of chronic CHD. About 250,000 patients died before the hospital stage. ventricular fibrillation was observed. The value of the standardized indicator of CHD prevalence in different cities differed significantly. Thus, the highest value of this indicator was noted in Baku, Kiev and Moscow (19.5%, 16.4% and 14.5%), and the lowest it was in Nalchik (6.9%). In Tashkent, the prevalence of CHD was 9.3%. Exertional angina pectoris is most common among the examined contingents (4.5%), somewhat less often (3.8%) there are "possible" ischemic changes on the ECG. Past myocardial infarction and painless forms of CHD are even less common (in 1.3% and 1.5%, respectively), and a possible history of myocardial infarction (not confirmed by ECG changes) was determined in 1.0%. Factors contributing to an increase in sudden death, along with such generally recognized risk factors as high blood pressure, hyperlipidemia, obesity, diabetes mellitus, etc., also include non-painful myocardial ischemia [9] and untimely establishment (or non- establishment) of diagnosis [16]. In France, a 20-year study of the causes of death of the population was carried out, which showed a decrease in mortality from cardiovascular diseases (CVD) by more than 30% [8]. In this regard, the issue of determining the range of risk factors for mortality from CHD and the development of adequate methods for the prevention of this disease is of particular importance. Summary data from studies conducted in three regions of France, two regions of Italy, two regions of Sweden, Barcelona, Belfast and Glasgow covered the population aged 35-64 years [10]. The authors concluded that the mortalityrate ofthepopulation is influenced byboth geographical location and lifestyle, diet and other factors. At the same time, it has been shown that one of the most important factors in the increase in mortality from CHD is a very low coverage of treatment of both patients suffering from CHDand thosewith high blood pressure. 98,7:ROTCAFTCAPMI .SECNEICSLACIDEM ,5202, enuJ,5emuloV gro.srehsilbupcimedaca.www Objective: To study therelationship between insulinresistance and increased cardiovascular risk. Introduction: Large population-based studies conducted by the Center of Cardiology of the Ministry of Health of the Republic of Uzbekistan indicate the importance and fairly high effectiveness of preventive measures against cardiovascular diseases [3,2,15]. Preventive programs implemented in production teams made it possible to increase the effectiveness of drug control of hypertension by 7 times, reduce the incidence of hypertension by 10%, and quit smoking up to 25% of men [2]. Multifactorial prevention in general was effective in both men and women [3]. However, it should be noted that the effectiveness of AH and smoking prevention was more pronounced among men than among women. Among men aged 30-59 years in Samarkand, the incidence of coronary artery disease was 3.4% in normal BP, 7.5% in borderline hypertension, and 16.7% in hypertension, respectively [3,4]. Studies in Tomsk were conducted among 647 patients with CHD, whose average age was 53.1  and 2.36 years, and it was shown that HDL-C has a stabilizing effect on atherosclerotic plaque and has a positive effect on the course of CHD, as well as to a certain extent prevents the development of MI [9]. Dyslipoproteinemia in some cases can be a manifestation of a general hereditary syndrome. In patients with a hereditary burden of cardiovascular diseases, hypertension was significantly more common among patients with dyslipoproteinemia than in patients with normolipidemia (20.2% and 12.5%, respectively). At the same time, the authors support the opinion that excess fat consumption contributes to an increase in blood cholesterol, and this, in turn, leads to an increase in the risk of developing CHD. A certain importance in the development of CHD is given to excess body weight (BMI). Most researchers note that the frequency of BMI among people engaged in mental work is higher than among people engag