SPECTROPHOTOMETRIC ANALYSIS OF 2-PHENOXYETHYLDIMETHYLBENZYLAMMONIUM-2-OXYNAPHTHOATE AND ITS CORRELATION WITH ANTIPARASITIC ACTIVITY

Аннотация

This study investigates the spectrophotometric characteristics of 2- phenoxyethyldimethylbenzylammonium-2-oxynaphthoate (PEDBA-ONA), a compound with promising antiparasitic potential. The analysis was performed using UV-Vis spectrophotometry to determine the absorption maxima and establish the stability of the compound in various solvents. In parallel, the antiparasitic activity of PEDBA-ONA was evaluated through in vitro bioassays against helminthic organisms. The correlation between the spectroscopic behavior and the observed biological activity was statistically analyzed to identify potential structure–activity relationships. The results demonstrate that PEDBA- ONA exhibits significant absorption in the UV region, consistent with the presence of conjugated aromatic systems, andthat itsantiparasiticactivity may be linkedto its molecular structure and photophysical properties. This research provides new insights into the development of ammonium-based compounds as effective antiparasitic agents and highlights therelevance ofspectrophotometric techniques in drugscreening. Keywords: 2-Phenoxyethyldimethylbenzylammonium-2-oxynaphthoate; ammonium compounds;helminthicbioassay; organic synthesis; drug screening. Introduction: Helminth infections remain a significant public health concern worldwide, particularly in developing regions where parasitic diseases are endemic. The growing resistance of helminths to existing anthelmintic drugs has prompted the search for novel compounds with improved efficacy and selectivity. Among the promising candidates are quaternary ammonium derivatives, which are known for their broad-spectrum biological activities, includingantimicrobial and antiparasiticeffects. Literature review: The search for effective antiparasitic agents has been a priority in medicinal chemistry due to the increasing prevalence of drug-resistant helminthic infections. Several studies have highlighted the potential of quaternary ammonium compounds as 98,7:ROTCAFTCAPMI .SECNEICSLACIDEM ,5202, enuJ,5emuloV gro.srehsilbupcimedaca.www bioactive agents with antimicrobial, antifungal, and antiparasitic activities. These compounds often act by disrupting cell membrane integrity or interfering with ion transport intarget organisms. Despite the promising profiles of many quaternary ammonium compounds, the specific spectroscopic properties and biological potential of 2- phenoxyethyldimethylbenzylammonium-2-oxynaphthoate (PEDBA-ONA) remain largely unexplored in the literature. This gap underscores the relevance of the present study in contributing to the field of antiparasitic drug development through combined spectrophotometricand biological evaluation.