OPTIMIZATION OF COMPREHENSIVE THERAPY FOR EXUDATIVE-HYPEREMIC AND EROSIVE-ULCERATIVE VARIANTS OF ORAL LICHEN PLANUS

Аннотация

This study explores optimized treatment strategies for the exudative- hyperemic and erosive-ulcerative variants of oral lichen planus (OLP), a chronic inflammatory disorder of the oral mucosa known for its persistent course, therapeutic resistance, and potential for malignant transformation. The research evaluates the distribution of clinical forms of OLP across different age groups and highlights the condition’s correlation with systemic illnesses and detrimental lifestyle factors such as smoking. Findings indicate that a tailored, multidisciplinary treatment approach significantly alleviates clinical symptoms, enhances mucosal healing, and contributes to a better quality of life for patients affected by OLP. Keywords: oral mucosa, oral lichen planus, exudative-hyperemic variant, erosive-ulcerative variant, integrated therapy, systemic comorbidities, risk factors. Oral lichen planus (OLP) is one of the most prevalent diseases affecting the oral mucosa (SMF), distinguished by its unknown etiopathogenesis, the presence of severe forms, a wide range of symptoms, potential for malignant transformation, and frequent resistance to therapy. These characteristics underscore its significant medical and social importance. [1] Among the different forms of OLP is the erosive-ulcerative form o damage to the mucous membrane of the oral cavity and the red border of the lips , the disturbance of eating due to pain , which leads to a decrease in the quality of life of patients.[2] Factors provoking the development of OLP develop as a result of a violation of the microbiocenosis of the oral cavity , a decrease in local and general immunity, stress, an increase in related somatic diseases, and the reception of certain drugs. Solving the problem of effective treatment of SMF OLP remains an urgent problem in dental practice .[3] Erythematous flatulence on the mucous membrane of the oral cavity (OLP) is one of the common, difficult to treat diseases, the etiology and pathogenesis of which have not been fully determined. According to scientific sources, OLP is important among inflammatory diseases of the oral mucosa, because it is characterized by pain, inconsistency and the possibility of transition to a poor quality form [4]. The severe course of OLP and its resistance to treatment prompt doctors and researchers to study this disease in depth [5]. https://scientific-jl.com/new 11 33 44 Volume–79_Issue-1_June-2025 JOURNAL OF NEW CENTURY INNOVATIONS There are different forms of OLP, among which exudative-hyperemic and erosive-ulcerative forms are of particular importance. These forms present with obvious signs on the oral mucosa and are painful for patients, affecting eating, speaking and daily activities (Silverman, 2005). The fact that severe forms of the disease in rare cases have the risk of transition to low-quality tumors indicates the need to study OLP as one of the important medical problems [6]. Recent studies confirm the role of various factors, including genetic, immunological, and psychogenic factors in the development of OLP. Stress conditions and related somatic diseases are among the factors that stimulate the development of OLP [7]. Therefore, it is important to use integrated approaches to increase the effectiveness of treatment of OLP. Various studies show that in the pathogenesis of OLP, the decrease of local and general immunity, the disturbance of the microbiocenosis in the oral cavity, and the effect of certain drugs are significant [8]. Accordingly, there is a need to improve therapeutic methods for effective treatment of various forms of the disease. The relevance of the research is determined by the fact that the complexity of the pathogenetic mechanisms associated with OLP in the mucous membrane of the oral cavity creates difficulties in the complete elimination of this disease. Therefore, the issue of increasing the effectiveness of complex treatment of exudative-hyperemic and erosive-ulcer forms of OLP in the mucous membrane of the oral cavity and improving the quality of life of patients remains an important problem in dental practice. The purpose of the study: improvement of complex therapy aimed at increasing the effectiveness of treatment of exudative-hyperemic and erosive-ulcer forms of erysipelas on the mucous membrane of the oral cavity. Research material and method. 122 people from 18 to 80 years old who were diagnosed with red squamous cell carcinoma of the oral mucosa (exudative-hyperemic and erosive-ulcer forms) were included in the study. the average age was 56.28±3.78 years. The average age of men (n=32) was 58.09±5.12 years, and the average age of women (n=90) was 54.47±2.44 years. The age of patients suffering from different forms of erysipelas was comparatively evaluated in SMF. The analysis showed that the average age of patients with the exudative-hyperemic form of SMF OLP was found to be significantly lower than that of patients with the erosive-ulcerative form of scarlet fever: 50.