Toxicity And Anti-Arrhythmic Activity 1- (4-Dimethylaminophenyl Dimethylaminophenyl) -6, 7-Dimethoxy-1, 2, 3, 4 Tetrahydroisoquinoline

Аннотация

The effect of 1 - (- 4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4- tetrahydroisoquinoloin hydrochloride (conditionally –F-24) on antiarrhythmicactivity in simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was studied on white out bred rats with the intravenous route of administration. It was found that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50) ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly more than the comparison drugs verapamil and lidocaine. Keywords: alkaloid, ant arrhythmic activity, isoquinoline alkaloids, cardio arrhythmic action.