Antibiotic resistance – a 21 st century threat

Аннотация

The discovery of penicillin by Alexander Fleming in 1928 and its subsequent isolation by Howard Florey and Ernst Chain in 1945 marked the beginning of a new era in the treatment of infectious diseases—antibacterial therapy. However, to date, more than 20-40% of antibacterial drugs are prescribed without adherence to the principles of rational antibiotic therapy. These principles include strict indications for drug administration, appropriate dosing and duration of treatment, and consideration of drug compatibility, among others.Globally, more than 700,000 deaths per year are attributed to infectious diseases, primarily caused by antibiotic-resistant bacterial strains. Respiratory tract infections have become among the most frequently encountered diseases, including within the structure of hospital-acquired infections.