The Therapeutic and Biological Role of Zinc and Vitamin D-3 In Children's Dermatology

Аннотация

Our work reflects aspects of the study of the role of zinc and vitamin D-3 based on literature analysis. Keywords: Dermis, function, layers, complications, vitamin. body. Introduction: The skin is the largest human organ, consisting of water, proteins, fats and minerals. It Numerous studies over the last three decades of the protects against microbes, regulates body temperature biological properties of vitamin D indicate its diverse and water balance. The structure of the skin includes effects on the human body. Vitamin D receptors have three main layers: the epidermis, dermis and been found in all organs and tissues of the human body, subcutaneous layer. which has led to the discovery of its non-calcemic (extraosseous) effects. The skin consists of three main layers: the epidermis, dermis and subcutaneous fat, which, in turn, consist of Research results have proven that a sufficient level of several internal layers. vitamin D in the body prevents various diseases and pathological conditions not only in the musculoskeletal Skin appendages such as hair follicles, sebaceous system, but also ensures the effective functioning of glands, and sweat glands also help the skin perform its the endocrine, cardiovascular, immune and other functions. systems. Lifestyle and external factors such as solar radiation The studies conducted have shown that vitamin D and temperature changes have a destructive effect on deficiency occurs among people of different age collagen and elastin, as well as on the structure of the groups, both in infants and young children, and in extracellular matrix. adolescents, and including adults and the elderly. In As we age, our natural production of collagen and infants and young children, vitamin D deficiency is one elastin slows down, and our skin's ability to retain of the leading causes of rickets, as vitamin D is moisture decreases. Skin loses tone and wrinkles necessary for the formation and maintenance of the appear. Learn more about what factors affect skin skeletal system. Intensive growth of young children, condition, why sun protection is needed, and how skin high rate of skeletal modeling with insufficient intake ages. the presence of phosphates and calcium in the body In the human body, the most important condition for and the imperfections of their transport and maintaining homeostasis is the effective performance metabolism pathways cause the rapid development of by the skin of at least two of its most important bone signs in infants and young children. functions: barrier, preventing the penetration of Although other functions of the skin (participation in foreign substances from the external environment into maintaining water balance, in metabolism, in gas the internal environment of the body, and exchange, in immune reactions, ensuring the synthesis thermoregulatory, ensuring the temperature of vitamin D and regulation of calcium metabolism, constancy necessary for the normal functioning of the protection from ultraviolet radiation, sensory function) International Journal of Medical Sciences And Clinical Research 20 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) play a very important role in ensuring the sustainable interleukin 4 (IL-4) does not decrease. With a significant functioning of the body. deficiency of this element and a block in the development of cells in the bone marrow, the number It is important to take into account that the borderline of B-lymphocytes decreases. position makes the skin very vulnerable to various external factors to which it is constantly exposed. The Myelopoiesis also suffers with prolonged zinc skin is protected from adverse effects can only be deficiency and increased production of provided under the condition of maintaining its normal glucocorticosteroids, and the number of neutrophils structure and adequate ability to perform functions - decreases. Zinc is essential for DNA replication two main, inextricably linked components of the life processes, as it plays a role in the functioning of more process of any organ and organism. than 100 transcription factors. Zinc affects the activity of key enzymes at the basic stages of replication and The unity of structure and function denotes the transcription. secondary nature of functional disorders in relation to the corresponding morphological changes at various These include DNA polymerases, thymidine kinase, levels, from the organismic to the microstructural and DNA-dependent RNA polymerase, aminoacyl biochemical. transcriptase, RNA synthetase. A whole group of transcriptional regulators contain Zn-containing Thus, the full functional activity of the skin as an organ protein domains in their structure, known as "zinc is possible only on the basis of its normal structure. In fingers". Zinc also increases the level of insulin-like providing this condition, in addition to genetic factors growth factor 1 - somatomedin, whi