Clinical-Laboratory Markers of Chronic Viral Hepatitis C

Аннотация

This article describes the prevalence and clinical features of 105 patients with chronic hepatitis. It was found that patients with chronic viral hepatitis have a high frequency of subjective or objective signs in the clinical picture and increased liver cytolysis according to laboratory tests. Key words: chronic hepatitis, liver, virus, subjective sign, objective sign The purpose of the study. Clinical and laboratory markers in patients with chronic viral hepatitis - assessment of liver function by determining biochemical parameters Materials and methods of research. During the study, data were obtained based on the results of a clinical and laboratory examination of 105 patients diagnosed with chronic viral hepatitis. 67 (63.8%) of the patients were women and 38 (36.1%) were men, their age ranged from 20 to 75 years (on average 44.2±3.2 years). During the survey, a comparative assessment of the health status of 60 healthy people aged 20-65 years was carried out. Results and analysis. As a result of the study, it was found that patients with chronic viral hepatitis have a high frequency of subjective or objective signs in the clinical picture and increased liver cytolysis according to laboratory tests. Conclusion. It has been established that chronic hepatitis occurs in the absence of subjective or objective signs from the clinical picture, from laboratory tests - indicators of liver cytolysis, elevated ALT values, total bilirubin, pigment caustic substances. Keywords: Chronic hepatitis, liver, virus, subjective sign, objective sign. Today, a number of scientific studies are being Introduction: Relevance and importance of the topic. conducted around the world to study the clinical and Viral hepatitis C is one of the main causes of chronic laboratory basis of chronic viral hepatitis, to prevent its liver diseases, and it is not only a medical, but also a complications through early diagnosis of the disease socio-medical problem due to its widespread and the development of treatment methods. However, distribution throughout the world, mainly observed the number of studies that would allow us to confirm when the population is incapacitated, severe this idea is extremely small, and the data in them are complications and transition to the chronic stage not reliable.Based on these considerations, the aim of [1,3,4,5]. our work is to assess liver function in patients with chronic viral hepatitis by determining clinical and Chronic viral hepatitis C is characterized by rapid laboratory markers and biochemical parameters. progression to fibrosis and, after 20–30 years, 20–45% of cases progress to cirrhosis and 5–15% to METHODS hepatocellular carcinoma. Chronic viral hepatitis C is often asymptomatic, and laboratory tests are also The study included data on the results of clinical, borderline [2,5,10,11]. laboratory and instrumental examinations of 105 patients diagnosed with chron International Journal of Medical Sciences And Clinical Research 24 https://theusajournals.com/index.php/ijmscr International Journal of Medical Sciences And Clinical Research (ISSN: 2771-2265) ic viral hepatitis. 67 (63.8%) of the patients were the condition of the parenchyma, the extrahepatic bile female, 38 (36.1%) were male, and their age ranged ducts, the vascular pattern of the liver, identifying signs from 20 to 75 (mean 44.2±3.2) years. The examination of portal hypertension: the presence of ascites, the results were assessed using a clinical-reference card diameter of the splenic vein > 10 mm, portal vein > 13 (questionnaire). mm, splenomegaly, redrainage of the umbilical vein was determined by parameters and the following signs The study was approved by the ethics committee of the were noted: liver enlargement, increased echogenicity Bukhara Medical Institute. Inclusion criteria: patients compared to the spleen, the density of the liver is aged 20-75 with chronic hepatitis; individuals who relatively reduced (hepato-spleen index is less than 1), provided written consent for clinical, laboratory and sound permeability is reduced, visualization of the instrumental examinations. portal and hepatic veins is worsened. Ultrasound elastography was performed in 105 patients to rule out Exclusion criteria from the study: alcohol or drug fibrosis in liver parenchyma. addiction, toxic hepatitis, alcoholic hepatitis, serious diseases (uncontrolled arterial hypertension, type 2 Biochemical tests of blood: alanine aminotransferase diabetes mellitus in the decompensation stage, chronic (ALT) and aspartate aminotransferase (AST), γ- heart failure III-IV functional class, patients with glutamyltranspeptidase (GGTP), alkaline phosphatase myocardial infarction and stroke), pregnant and (IF), total bilirubin, total protein and its fractions, blood lactating women. clotting system activity were studied. To rule out alcoholic liver disease, a history (absence of The obtained data were statistically processed using regular alcohol consumption) was coll