THE EFFECT OF CHEMOTHERAPY ON THE SQUAMOUS EPITHELIUM OF THE CERVIX

Аннотация

The squamous epithelium of the cervix (cervix) is one of the most common tumor localizations in women. The development of these tumor processes is often associated with the Human Papillomavirus (HPV), which is one of the main causes of cervical cancer and its primary lesions. In modern medicine, surgery, radiotherapy and chemotherapy are used to treat this disease. This article analyzes the effect of chemotherapy on the squamous epithelium of the cervix and its clinical effectiveness. Cervical cancer is the second or third most common type of cancer among women worldwide, with approximately 0.5 million cases recorded annually. In 1980, the number of cervical cancer cases was estimated at 378 thousand, butin recent years this figure has reached 500thousand per year. Keywords: Cervix, human papillomavirus, cervical cancer, radiation therapy, chemotherapy, squamous epithelium,clinical efficacy, tumor, surgery, radiotherapy. Materials andMethods This study included 50 patients with squamous cell carcinoma of the cervix. Their ages ranged from 30 to 60 years, and all had stage II or III disease. Patients were treated with neoadjuvant chemotherapy (NC) based oncisplatin and paclitaxel. The following parameters were studied during thestudy: •Theeffect ofchemotherapy oncellular structures (byhistological examination). •Clinical efficacy indicators (indicators ofremission or progression). •Frequency and severity ofsideeffects.