ОЦЕНКА ЛАБОРАТОРНЫХ ПОКАЗАТЕЛЕЙ НАРУШЕНИЙ КОАГУЛЯЦИОННОГО ГЕМОСТАЗА У БОЛЬНЫХ С САРСКОВОЙ ИНФЕКЦИЕЙ-2

Аннотация

To evaluate the indicators of coagulation hemostasis in patients with SARSCoV-2 and the early laboratory diagnosis of the development of hypercoagulability in patients with secondary disease and the development of intravascular thrombosis in patients with SARSCoV-2. The study material was obtained from 80 patients with SARSCoV-2. Keywords: SARSCoV-2, Coagulation-hemostasis, D-dimer. 166 Universal International Scientific Journal 2025, 2(5) Language: Uzbek Citation: Olimjonov , J., & Djo’rabayev , T. (2025). ASSESSMENT OF LABORATORY INDICATORS OF COAGULATION HEMOSTASIS DISORDERS IN PATIENTS WITH SARSCOV-2. Universal International Scientific Journal, 2(5), 166–169. Retrieved from https://universaljurnal.uz/index.php/jurnal/article/view/1988 Copyright © 2025 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Dolzarbligi: SARSCoV-2 butun dunyo gemostazni shikaslanishini laboratoriya bo'ylab tez tarqalgan, og'ir asoratlar bilan tashxisi. kechadigan, yangi, infeksion kasallikdir. Material va metodlar: Tadqiqot Ba'zi ma’lumotlar shuni ko'rsatadiki, obʼekti sifatida 2 Zangiota yuqumli yuqtirgan odamlarning 80% da yengil va kasalliklar shifoxonasida davolangan Covid- o’rta og’ir klinik kechishi kuzatilib, jiddiy 19 bilan og’rigan 80 ta bemorlar olindi. 1- tibbiy yordamga va statsionar davoga muxtoj guruhga 25 (31,25%) ikkilamchi kasligi bo'lmaydi [1] bo’lmagan SARSCoV-2 bilan og’rigan SARSCoV-2- bitta zanjirli RNK virusi bemorlar, 2-guruhga 30 (37,5%) ta Covid-19 va koronaviruslar oilasiga tegishli. Virus bilan og’rigan, arterial gipertenzensiyasi bor hujayralarga hujayra yuzasida joylashgan bemorlar. 3-guruhga 25 (31.25%) Qandli angiotensinni o'zgartiradigan ferment 2 diabetti bor SARSCoV-2 bilan og’rigan (ACE-2) retseptorlari orqali kiradi [2]. ACE- bemorlar. Nazorat guruhiga yoshi va jinsiga 2 retseptorlari nafas olish yo'llari, buyraklar, mos ravishda 15 nafar sog’lom odamlar qizilo'ngach, siydik yo’lari, qovuq, ichak, olindi. yurak, markaziy asab tizimi hujayralarida Tekshirish usullari:. APTT, AT, D- mavjud. Biroq asosiy nishon hujayralari II dimer, Fib, PT, PT-act, TT; tekshiruv Mindray turdagi alveolootsitlar [3] C2000-2 koagulometrida “Human” Reagentini Nafas olish buzilishi kasallikning qo’langan holda o’tqazildi. asosiy xususiyati bo'lsada, dastlabki Natijalar. 1-guruh bemorlari va tadqiqotlar shuni ko'rsatadiki, aylanma D- nazorat guruhi solishtirilganda, AT (91.24% dimer darajasining ko'tarilishi o'lim xafini va N-98.82%; p <0.001);PT (12.80 sek va N- oshiradi.[4.5] 12.08 sek; <0.001);va TT (20.25 sek va N- COVID-19 bilan og’rigan bemorlarda 18.34 sek; <0.01);ikki guruh o'rtasida normal aniq koagulyatsiya buzilishi aniqlandi. ko’rsatgichlarni ko’rsatdi. Ushbu gipotezani tasdiqlash uchun Covid-19 APTT (32.30 sek va N-28.65 sek ; bemorlarini autopsiya tekshiruvlari mayda <0.01); D-dimer (0.8 va N-0,26 mkg/ml; p tomirlar va kapilyarlar ichida fibrin <0,001); FIB 4.30 g/L va 2.90 g/L; <0.001) trombining mavjudligini ko’rsatdi [6]. bemorlarda nazorat guruhiga qaraganda Tadqiqot maqsadi: SARSCoV-2 yuqori (1-jadval). og’rigan bemorlarda koagulyatsion 167 Universal International Scientific Journal 2025, 2(5) 2-guruh bemorlarida nazorat guruhiga 3-guruh bemorlarida nazorat guruhiga qaraganda APTT (36.45 sek va N-28.65 sek; qaraganda APTT (45.25 sek va N-28.65 sek; <0,05); PT (14.12 sek va N-12.08 sek; <0,05);PT (17.20 sek va N-12.08 sek; <0.001); TT (25.20 sek va N-18.34 sek; <0.001); TT (30.45 sek va N-18.34 sek; <0.001); D-dimer (1.5 mkg/ml va N- <0.001); D-dimer (2.4 mkg/ml va 0.26mkg/ml; <0.05), Fib (7.12 g/L va N-2.90 0.26mkg/ml; <0.05), Fib (9.40 g/L va 2.90 g/L; <0.05) nazorat guruhiga qaraganda g/L; <0.05) nazorat guruhiga qaraganda yuqori. sezilarli ko’paygan. (1-jadval). AT (70.30 % va N-98.82%; <0.001) AT (60.35% va N-98.82%; <0.001) nazorat guruhiga qaraganda kamaygan (1- nazorat guruhiga qaraganda kamaygan. (1- jadval). jadval). Jadval-1 Koagulogramma SARS-CoV- SARS-CoV- SARS-CoV- Nazorat Parametrlari. 2. 1-guruh 2. 2-guruh 2. 3-guruh guruhi (n = 25) (n = 30) (n = 25) (n = 15) APTT, s 32.30 ± 2.3 36.45 ± 1.25 45.25 ± 1.3 28.65 ± 3.03 AT, % 91.24 ± 2.4 70.30 ± 4.5 60.35 ± 3.4 98.82 ± 3.91 D-dimer, mkg/ml 0.8± 0.12 1.5 ± 0.28 2.4 ± 0.5 0.26 ± 0.18 FIB, g/L 4.30 ± 1.10 7.12 ± 1.35 9.40 ± 2.20 2.90 ± 0.53 PT, s 12.80 ± 2.3 14.12 ± 1.54 17.20 ± 2.25 12.08 ± 2.28 TT, s 20.25 ± 1.50 25.20 ± 1.65 30.45 ± 0.80 18.34 ± 0.92 Koagulogramma TT Pt Fib D-dimer AT APTT funksiyasi bajaradi, shunday 0 20 40 60 80 100 120 bo’lsada COVID- 4-guruh 3-guruh 2-guruh 1-guruh 19 bilan og’rigan bemorlarda gemostaz tizimi ikkilamchi Umuman olganda bizning natijalar ham kasaligi bor bemorlarda buzilish xafi yuqori oldingi tekshirilgan natijalarga mos keladi, bo’ladi. qon ivish jarayoni organizimni himoya COVID-19 kasallarida qon ivishi tizimi ikkilamichi kasaligi bor bemorlarda nazorat gu