STUDY OF THE MAIN SERUM CYTOKINES IN PATIENTS WITH LIVER ECHINOCOCCOSIS

Аннотация

We examined 54 patients with liver echinococcosis aged 17-70 years who were hospitalized at the Bukhara Regional Multidisciplinary Medical Center in 2019-2024. The control group consisted of 30 donors aged 18 to 30 years (18 men and 12 women). Clinical examination and specific immunological examination were performed before surgery, on the 1st, 3rd, 5th days. In 53 patients with liver echinococcosis, the levels of IL-1 betta , IL-4 and IL-6 in peripheral blood serum were determined. Echinococcosis of the liver is accompanied by immunosuppression, which is expressed in the suppression of the production of IL-1 betta and an increase in the anti-inflammatory interleukin IL-6, which in turn leads to tension in the humoral and cellular parts of the immune system. Serum concentration of IL-6 is a reliable diagnostic and prognostic criterion for the prognosis of this disease.