OVERWEIGHT, PRO-INFLAMMATORY STATUS AND DYNAMICS OF NTPROBNP IN LIVE RELATED KIDNEY TRANSPLANTATION DONORS AS MODIFYABLE FACTORS OF CARDIOVASCULAR RISK

Аннотация

Optimal related kidney transplant donors were predominantly overweight, which correlated with the intensity of subclinical inflammation and endotoxemia. An increase in IL-6 and CRP in donors correlated with both age and BMI, proving the contribution of visceral fat depot to the implementation of subclinical inflammation. The age of the donor affected the levels of NTproBNP, SBP, DBP, IL-6, and CRP. Donor mothers had a statistically significantly elevated level of SMP and TNF-alpha, a significantly lower baseline GFR relative to the general group of donors. The level of GFR and NTproBNP in donors was within the reference interval before nephrectomy, however, GFR decreased statistically significantly, and NTproBNP increased by 24.2% on the 2nd day after nephrectomy both in the general group and in donors – mothers – by 27.5% from the initial and exceeding 125 pg/ml, reflecting adaptive responses after nephrectomy.