IMMUNODEFIENCY CONDITIONS IN COMBINATION - ACQUIRED PNEUMONIA OF A LONG COURSE IN CHILDREN

Аннотация

The risk factors for the development of prolonged pneumonia are the background of concomitant diseases, the age of the patient, the severity of the inflammatory process and the virulence of the pathogen. Resistance of bacterial pathogens plays an important role in the formation of a prolonged course of pneumonia. The analysis of cytokine status indicators revealed the most informative criteria to predict the development of the spread of the inflammatory process. Quite high levels of the cytokine IL-1β, 8 and TNF-α were characteristic, significantly exceeding those in the control group. The analysis of the results showed that in the case of CAP of a protracted course, the level of IL-1β increased by 3.8 times compared with the data of the control group, which averaged 105.8±8.9 pg/ml (P<0.01). Analysis of the microbial spectrum of causative agents of community-acquired pneumonia of a protracted course showed a high frequency of isolation of problematic multi-resistant microorganisms, which can become a determining factor for the outcome of the disease.