EPIDEMIOLOGY, ETIOLOGICAL INTERRELATION AND PROGNOSTIC CONSEQUENCES OF DEPRESSION AND ANXIETY IN CORONARY HEART DISEASES

Аннотация

Ischemic heart disease (CHD) and depression are common. Depression is more common in patients with CAD than in the general population. People with depression are more likely to eventually develop CAD and have a higher mortality rate than the general population. Patients with CAD who are also depressed have a worse outcome than those who are not depressed. There is a graduated relationship: the more severe the depression, the higher the subsequent risk of mortality and other cardiovascular events. It is possible that depression is only a marker of more severe CAD, which still cannot be detected with our currently available studies. However, given the increased prevalence of depression in patients with CAD, a causal relationship is likely with either CAD causing more depression or depression causing more CAD and worse CAD prognosis. There are many possible pathogenetic mechanisms that have been described that are plausible and that may well be important.