CARDIOVASCULAR RISK FACTORS AND EXPRESSION LEVEL OF MICRORNA IN PATIENTS WITH MYOCARDIAL INFARCTION

Аннотация

Cardiovascular risk factors contribute to the development of cardiovascular disease and their presence may affect the level of microRNA expression in patients with ST-elevation myocardial infarction. So far, only a few reports have been published describing the relationship between microRNA expression and the presence of cardiovascular risk factors. Aim Evaluation of microRNA expression in patients with ST- elevation myocardial infarction with present cardiovascular risk factors. Materials & Methods Seventeen patients with ST-elevation myocardial infarction were examined. MicroRNA expression (miR-1, miR-208a i miR-423-5p) was determined according to the Pfaffla model and then compared between two groups: with and without cardiovascular risk factors. Results Higher expression levels of microRNAs were found in smokers. Lower levels of miR-1, miR-208a and miR-423-5p expression were found in patients with increased lipid levels or these using hypolipemic drugs. Conclusion MicroRNA expression in patients with ST-elevation myocardial infarction depends on the presence of some cardiovascular risk factors.