EXPERIMENTAL - MORPHOLOGICAL AND CLINICAL SUBSTANTIATION OF CHEMOTHERAPY IN THE PREVENTION OF RECURRENT LIVER ECHINOCOCCOSIS

Аннотация

Objective: to improve the results of treatment of patients with liver echinococcosis by optimizing the methods of surgical treatment and chemotherapy.Methods: Clinical study included 371 patients with EN. In order to study the effect of albendazole in various dosages on the germinal forms of echinococcosis, a morphological study of the internal organs of experimental animals (32 sheep) infected with echinococcosis in natural conditions was carried out.Results: optimization of the tactics of surgical treatment of liver echinococcosis, taking into account the choice of access, method of treatment and elimination of the residual cavity, as well as correction of the course of prophylactic chemotherapy, improved the quality of care by reducing the frequency of immediate postoperative complications from 12.5% to 4.3% and recurrence of the disease from 11.9% to 2.6%. Conclusions: Albendazole dose adjustment for the prevention of liver echinococcosis recurrence in patients with concomitant chronic diffuse liver pathology is clinically justified. 14±0.11 to 0.62±0.05 mmol/l in the main group and AST from 0.72±0.07 to 0.52±0.04 mmol/l.