EVALUATION OF THE RATIONALITY OF COMBINATION THERAPY IN THE TREATMENT OF RESPIRATORY DISEASES

Аннотация

Antibacterial drugs, as well as their combinations, are widely used in clinical practice. Irrational combinations in antibacterial therapy can lead to adverse drug reactions and/or increased costs in the healthcare system, as well as to the development of microbial resistance to antibacterial drugs as a result of a decrease in the effectiveness of pharmacotherapy. In 27% of cases of respiratory diseases, combined antibacterial therapy was performed, in 93% of cases, combination therapy consisted of 2 antibacterial drugs, in the remaining 7% of cases, combination therapy consisted of 3 antibacterial drugs. In 10% of cases, respiratory diseases were accompanied by liver and kidney damage, and the nephrotoxicity or hepatotoxicity of antibacterial drugs used in combination therapy and their pharmacokinetic properties were not taken into account.