STATE OF THE IMMUNE SYSTEM AND THE DEVELOPMENT OF POST-TRANSFUSION COMPLICATIONS IN PATIENTS WITH HEMOPHILIA

Аннотация

The aim of the study is to study the immune status in patients with hemophilia. A complex of immunological studies aimed at determining individual populations and immunoregulatory subpopulations of lymphocytes was carried out in 45 patients with hemophilia, of which 25 suffered from a severe form and 20 were diagnosed with a moderate form of hemophilia. 16 practically healthy men were examined as a control group. The results of studies show that hemophilia is accompanied by a violation of the immune status in patients, which manifests itself in changes in the cellular even (a sharp decrease in the total pool of T-lymphocytes and its subpopulation - TGF cells, with significantly high values ​​of TGF cells) and humoral immunity (increase in the content of B- lymphocytes, severe dysimmunoglobulinemia with a decrease in the content of immunoglobulin A and an increase in the level of immunoglobulins M and G). The data of the FAN and CEC studies also confirm the fact of impaired immunoreactivity in patients with hemophilia: the FAN indicators are reduced, resulting in an increase in the CEC.