EVALUATION OF THE PROGNOSTIC SIGNIFICANCE OF THE INTENSITY AND FREQUENCY OF COUGH IN PATIENTS WITH INTERSTITIAL LUNG DAMAGE

Аннотация

The intensity and frequency of coughing in interstitial lung disease (ILD) remain unclear. Purpose of the study. To assess the intensity and frequency of cough in nonspecific interstitial pneumonia (NsIP), interstitial lung disease in systemic connective tissue diseases (IIP-CCTD) and COVID-19 associated interstitial pneumonia (COVID-19AIP) and to study their correlation with clinical indicators. Materials and research methods. In this study, cough intensity and frequency were assessed using subjective qualitative cough assessment (cough or no cough), quantitative methods including the Listner Cough Questionnaire (LCQ-Leicester Cough Questionnaire), Visual Analogue Cough Scale (VAS), diary cough severity diary and CQLQ-cough-specific quality of life questionnaire, as well as chronic dyspnea scale and frequency scale. cough in gastroesophageal reflux disease (GERD). Correlations between cough intensity and frequency with potential predictor variables were tested using bivariate and multiple logistic regression analyses. Results. The study included: 200 patients with NSIP, 49 with IIP-MCTD and COVID-19AIP-59 patients, respectively. Patients with NSIP and COVID-19AIP had the highest cough intensity among the study groups. In patients with NSIP and COVID-19 AIP, both intensity and frequency of cough were negatively correlated with lung diffusivity. In IIP-MCTD, both intensity and frequency of cough correlated with a higher FSSG score (Frequency scale for the Symptoms of GERD). In a multivariate analysis of patients with IIP-CCTS, the FSSG score was independent and associated with both cough components. Finally, we examined the features of the differences between the intensity and frequency of cough in all three groups of patients. Patients in whom the frequency and intensity of cough prevailed over the rest of the clinical symptoms had a more pronounced deterioration in health indicators (CQLQ cough quality of life questionnaire) compared with other patients. Findings. Cough intensity was higher with NSIP and COVID-19AIP compared with IIP-MCTD. Various clinical parameters correlated with the intensity and frequency of cough depending on the subtype of IIP-MCTS. Cough frequency was strongly associated with subjective health status, compared to cough intensity. The data obtained by us in assessing the intensity and frequency of cough indicate the need to manage patients, taking into account the objective and subjective factors associated with cough.