MODERN ASPECTS OF POLYMORPHIC GENES OF MATRIX METALLOPROTEINASES AND ITS TISSUE INHIBITORS IN CHILDREN WITH CHRONIC GLOMERULONEPHRITIS AND PROGNOSIS OF THE DISEASE

Аннотация

An imbalance between the activity of MMPs and their inhibitors leads to the accumulation of the extracellular matrix and obliteration of the glomeruli, which contribute to the development of fibrosis and sclerosis of the renal vessels. These disorders can affect the processes of filtration and reabsorption. Therefore, the amount of Cystatin C-, which is a gold marker in the diagnosis of kidney disease, in the blood of patients with chronic glomerulonephritis increases. The amount of Cystatin C in the blood increases until clinical symptoms appear. The more severe the renal pathology, the worse Cystatin C is filtered in the kidneys, the higher its level in the blood. The connection of MMP and TIMP with Cystatin C explains the aggravation of the process.