INFLAMMATORY MARKERS AND DISEASE SEVERITY IN NEWBORNS WITH PROLONGED HYPERBILIRUBINEMIA

Аннотация

Prolonged neonatal hyperbilirubinemia is a disease based on an increase in bilirubin, which is clinically manifested by hyperbilirubinemia for more than 14 days. Given the neurotoxicity of bilirubin on the body of a newborn, a study was also made of markers of inflammation to determine the severity of the disease. Markers of inflammation are known to be used for the differential diagnosis of viral or bacterial etiology of the inflammatory process. To study, we carried out a leukocyte count, a biochemical analysis of blood serum for bilirubin and fractions, as well as inflammation markers C-reactive protein and procalcitonin. This article discusses the difference in the reaction of inflammatory markers depending on the level of bilirubin and the use of pathogenetically scientifically based initial antibiotic therapy in the absence of bacteriolytic confirmation of infection. The difference in the reaction of inflammation markers depending on the perinatal background allows using it for pathogenetically scientifically substantiated starting antibiotic therapy. Distinction of the reaction of markers of inflammation depending on against a background of prenatal infection possible to use for pathogenetic scientifically grounded launching antibiotic therapy lacking bacteriolytic confirmation of infection.