ESTIMATION OF THE EFFICIENCY OF ANTISSEAL COATING ON THE MODEL OF LUNG WOUND IN EXPERIMENT

Аннотация

Postoperative adhesion formation is the most common complication in general surgical practice with a frequency of more than 90% after abdominal surgery and up to 70% after thoracic surgery (Aysan E. et al. 2020, Banka R. et al. 2018). The frequency of relaparotomy and retorakotomy, according to various literature data, is estimated at 63% -97% (Bhatnagar R. et al. 2016, De Wilde RL et al. 2016). Repeated surgical procedures are more time-consuming and technically difficult, which, in turn, creates a potential risk of damage to vital structures. The paper analyzes the results of experimental and morphological studies, substantiates the effectiveness of the prevention of adhesion formation by using a domestic anti-adhesion agent in the form of a powder from cellulose derivatives. The biological safety of the new anti-adhesive coating has been determined under experimental conditions. 32 white outbred rats were used as experimental animals.