CLINICAL FEATURES, COURSE AND DIAGNOSIS OF GUILLAIN-BARRE SYNDROME

Аннотация

Guillain-Barre syndrome (GBS) is a very rare autoimmune disease that is associated with demyelination of the peripheral nervous system and progressive muscle weakness that occurs mainly in previously healthy people. The incidence of GBS is 1.1-1.8 cases per 100,000 per year, and the incidence increases with age. The clinical spectrum of GBS is heterogeneous and includes acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), acute motor and sensory axonal neuropathy (AMSAN), and Miller Fisher Syndrome (MFS). The disease is usually characterized by a rapid onset of symmetrical limb weakness, which progresses within a few days to 4 weeks and occurs in patients of any age. In developed countries, GBS has become the most common cause of acute flaccid paralysis. Despite improved recognition and treatment, GBS continues to be a serious disease.