NEUROPHYSIOLOGICAL AND BIOCHEMICAL CRITERIA IN THE DIAGNOSIS OF PROGRESSIVE MUSCULAR DYSTROPHIES

Аннотация

A comprehensive clinical examination, electroneuromyography (ENMG), electromyography (EMG), biochemical tests (creatine kinase, lactate dehydrogenase, aminotransferases, troponin I), and inflammatory markers (interleukins, TNF-α) were performed in 25 patients with progressive muscular dystrophy. Creatine kinase levels were elevated in all patients, averaging 2840±1650 U/L. The highest values ​​(4250±1980 U/L) were observed in patients with Duchenne muscular dystrophy. Electromyographic studies revealed myopathic changes in all patients: PDE amplitude was 485±180 μV, duration was 7.2±2.1 ms, and polyphasicity was 28.4±8.6%. Elevated troponin I levels were detected in 8 patients (32%). Most patients had elevated inflammatory markers (IL-1β, IL-6, TNF-α). Comprehensive diagnostics are highly effective in detecting progressive muscular dystrophy, increasing diagnostic accuracy to 92% and improving differential diagnosis of various forms of the disease.