EFFICACY OF LOW-FREQUENCY TRANSCRANIAL MAGNETIC STIMULATION (TMS) IN THE CORRECTION OF PARESIS IN ISCHEMIC STROKE

Аннотация

Objective. To evaluate the efficacy and safety of low-frequency (1 Hz) rTMS targeting the M1 cortex of the unaffected hemisphere in post- stroke paresis. Methods. A prospective randomized controlled trial (RCT) with parallel groups included 60 patients with ischemic stroke and moderate/severe paresis (MRC 2–3 points). The main group (n=30) received standard rehabilitation + LF-rTMS (1 Hz, 80% RMT, 1200 pulses/session, 10 sessions), while the control group (n=30) received only rehabilitation. Assessments using FMA, MRC, WI, mRS, and MAS scales were conducted at baseline (T0), post-treatment (T1), and at 3 months (T2). Results. The main group vs. control showed significant (p<0.05) improvements: FMA-UE: +10.2±2.5 points (control +4.0±1.8); Muscle strength (MRC): +1.5±0.4 points (control +0.6±0.3); WI: +35.1±8.0% (control +14.2±5.2%); mRS: reduction by 1.1±0.3 points (control -0.5±0.2); MAS: spasticity decrease by 0.9±0.3 points (control -0.3±0.1). No adverse effects occurred. Conclusion. LF-rTMS (1 Hz) is a safe and effective method for correcting post-stroke paresis, significantly improving strength, motor function, reducing spasticity, and enhancing functional independence. Recommended for inclusion in neurorehabilitation programs.