GENERAL STATUS OF CYTOKINES IN ACUTE OBSTRUCTIVE BRONCHITIS IN FREQUENTLY ILL CHILDREN

Аннотация

Acute obstructive bronchitis remains one of the most common and severe diseases of the respiratory system in children. The main direction of our scientific research was to study the mechanisms of development, establish the characteristics of the clinical course, assess the role of the immune status, cytokines in acute obstructive bronchitis in frequently ill children, to develop pathogenetic methods of treatment and preventive measures. Purpose of the scientific research: To study the state of cytokines in acute obstructive bronchitis in frequently ill children. Material and research methods. To establish the relationship with the cytokine profile indicators, a survey was conducted of 120 patients with acute obstructive bronchitis, divided into 2 groups: Group I - 40 patients with acute obstructive bronchitis from the group of “occasionally ill children”; Group II - 80 patients with acute obstructive bronchitis from the group of “frequently ill children”. Research results. The decrease in IL-4 levels in children of group II (9.60±0.18 pg/ml), in comparison with patients of group I (12.60±0.24 pg/ml, P<0.001), indicates less pronounced allergic processes observed in AOB in children with acute respiratory syndrome. It was revealed that immunological markers of AOB can be high values ​​of the studied interleukins of the anti-inflammatory (IL-1 by 4.8 times, IL-4 by 2.6 times, IL-10 by 2.2 times) and pro-inflammatory (IL-6 by 1.1 times, IL-8 by 1.9 times and TNF-α by 1.2 times) classes, in comparison with standard indicators (P<0.01, P <0.001), which indicates their importance in the pathogenetic mechanisms of the inflammatory process and the suppression of the mechanisms of immune status in biofeedback. Conclusions. The study showed that cytokines are one of the key mediators of pathogenesis, regulating the recruitment and activation of immune cells and inflammatory processes in the respiratory tract. Understanding the role of cytokines in obstructive bronchitis in children can provide insight into the mechanisms, features of the course, potential diagnostic and therapeutic measures of the disease.