PSYCHOSOMATIC ASPECTS OF NEUROLOGICAL AND PSYCHOEMOTIONAL CHANGES IN WOMEN WITH PRECANCEROUS UTERINE DISEASES

Аннотация

The role of psychological factors in the pathogenesis of precancerous diseases of the reproductive system remains underexplored. The aim of the study was a comparative assessment of the psychoemotional state and biological markers of stress in women with two diseases of different etiologies: human papillomavirus (HPV)-associated cervical intraepithelial neoplasia (CIN, n=38) and endometrial hyperplasia (EH, n=32) associated with hormonal imbalance. Compared to the control group (n=40), both main groups showed significantly higher levels of anxiety and depression on the HADS scale (p<0.001). This psychological distress correlated with a disturbed diurnal profile of the stress hormone cortisol and changes in brain activity on EEG. Regardless of the disease's cause, a "precancerous" diagnosis triggers universal psychosomatic processes. These processes, in turn, are a significant pathogenetic factor that may negatively affect the function of the immune (in the case of CIN) and hormonal (in the case of EH) systems.