PATHOGENETIC ROLE OF GLYMPHATIC INSUFFICIENCY IN CHRONIC CEREBRAL ISCHEMIA

Аннотация

Chronic cerebral ischemia is accompanied by impaired function of the glymphatic system, leading to reduced clearance of metabolites and accumulation of toxic proteins (β-amyloid, tau protein). These changes aggravate neurodegeneration, contribute to the development of cognitive impairment, and promote vascular-degenerative dementia. The key mechanisms of glymphatic insufficiency include decreased arterial pulsatility, loss of aquaporin-4 polarity, and impaired cerebrospinal fluid dynamics. Promising therapeutic strategies involve restoration of vascular function, modulation of aquaporin-4, and normalization of sleep.