VITAMIN D DEFICIENCY IN HIGH-RISK PRE-ECLAMPSIA PATIENTS AND LABORATORY BLOOD CHANGES

Аннотация

PE is responsible for almost 100 000 maternal deaths annually worldwide. Despite some advances in the study of PE, it is still a major cause of maternal mortality with no clear trend towards improvement [1, 2, 5]. Recent studies in different countries have drawn attention to the potential of vitamin D to reduce the risk of PE. It is believed that the active form of vitamin D-1,25 (OH) 2D regulates the transcription and function of genes related to trophoblast invasion, normal implantation and angiogenesis. Vitamin D (1α,25-dihydroxyvitamin D3) exerts its effects on cells through both genetically mediated and non-genetic pathways. They include both long-term modulation of gene expression (genetic mechanism) and short-term activation of intracellular communication (non-genetic mechanism).