MOLECULAR GENETIC FACTORS OF PREECLAMPSIA AND THEIR ASSOCIATION TO THE COURSE AND OUTCOME OF PREGNANCY

Аннотация

Preeclampsia (PE) is a disease that continues to be the main cause of maternal and fetal mortality and complications in 5-8% of pregnancies, Preeclampsia develops after 20 weeks of pregnancy and is characterized by hypertension and proteinuria. According to WHO, hypertension during pregnancy is the cause of 9 to 25 per cent of all maternal mortality, but accurate data are difficult to determine. In addition to the fact that PH is one of the leading causes of maternal and perinatal mortality, this disease and its complications cause a range of medical problems. There are still no new early methods for predicting preeclampsia. Preeclampsia is defined as hypertension and proteinuria in the second half of pregnancy and is one of the most complex diseases known in obstetrics. Although there is now some progress in the discovery of the pathophysiology of preeclampsia, conflicting theories still exist and the debate is certainly relevant. According to WHO, one in five children born to a mother with pre-eclampsia has impaired physical and psycho-emotional development, with higher morbidity rates in infancy and early childhood.