A COMPARATIVE HISTOMORPHOMETRIC EVALUATION OF BONE TISSUE REGENERATION DURING EXPERIMENTAL USE OF GENE-ACTIVATED OSTEOPLASTIC MATERIALS IN GEL CARRIER

Аннотация

This study presents a comparative histomorphometric evaluation of bone tissue regeneration using gene-activated alginate and collagen gels. The primary focus is on the effect of VEGF-A165 on the bone formation process in the central part of the regenerate. The results demonstrate that the addition of VEGF-A165 to the gels significantly enhances bone regeneration compared to gels without this growth factor. A substantial increase in the volume of newly formed bone tissue was observed in the central part of the regenerate when using gene-activated gels with VEGF-A165. These findings highlight the potential of incorporating VEGF-A165 in biomaterials to stimulate effective bone tissue regeneration. The data obtained can be crucial for the development of new treatment strategies and the improvement of clinical approaches for the repair of bone defects.