THE INFLUENCE OF SPINAL ANESTHESIA ON THE PROLONGATION OF THE QT INTERVAL IN PATIENTS WITH DIABETES MELLITUS

Аннотация

The aim of this study was to investigate the effect of spinal blockade on the QTc interval in patients with and without diabetes mellitus, considering the known impact of spinal anesthesia and autonomic neuropathy on QTc interval prolongation. Both spinal anesthesia and autonomic neuropathy, often observed in diabetes mellitus, are associated with QTc interval prolongation. However, the specific impact of spinal blockade on the duration of the QTc interval in individuals with diabetes had not been thoroughly studied. We hypothesized that patients with diabetes would experience greater QTc interval prolongation after spinal blockade compared to non-diabetic patients. In this prospective observational study conducted at a tertiary-level university clinic: SamSMU multi-profile clinic, 48 participants were divided into two groups: with diabetes mellitus (DM group, n=24) and without it (control group, n=24). All subjects underwent spinal anesthesia. Measurements of the QTc interval, the interval from the peak to the end of the T wave (Tp-e interval), heart rate variability, blood pressure, and heart rate were recorded at baseline (T1) and 1 (T2), 5 (T3), and 10 minutes (T4) after spinal blockade. Our findings suggest that patients with diabetes experience more pronounced QTc interval prolongation after spinal anesthesia compared to non-diabetic patients. These results underscore the importance of monitoring cardiac electrical activity in patients with diabetes.